Download Death Receptors in Cancer Therapy by E. Robert McDonald III PhD, Wafik S. El-Deiry MD, PhD PDF
By E. Robert McDonald III PhD, Wafik S. El-Deiry MD, PhD (auth.), Wafik S. El-Deiry MD, PhD (eds.)
Cell demise, or apoptosis, performs a massive function in organic techniques and affliction and gives targeted possibilities to boost new remedies for melanoma, autoimmune illness, stroke, center assault, and Alzheimer's affliction. In loss of life Receptors in melanoma treatment, prime physician-scientists and easy researchers assessment extensive our most recent figuring out of the molecular occasions that keep watch over mobile demise, illuminating these molecules that offer pursuits for agonists or antagonists designed to modulate dying signaling for healing reasons. The authors concentrate on the extrinsic method of dying receptors, their law and serve as, and their abnormalities in melanoma. themes of particlar curiosity contain resistance to apoptosis, path signaling, demise receptors in embryonic improvement, mechanisms of caspase activation, and demise receptor mutations in melanoma. extra chapters deal with loss of life signaling in cancer, artificial retinoids and dying receptors, the function of p53 in dying receptor law, immune suppression of melanoma, and mixture remedy with loss of life ligands.
Authoritative and updated, loss of life Receptors in melanoma remedy bargains a well timed compendium of cellphone dying signaling pathways for these looking both a easy realizing of apoptosis or the information had to improve new therapeutics that might turn on or block loss of life signaling in disease.
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Additional info for Death Receptors in Cancer Therapy
Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995;83:1243–1252. 88. Roy N, Deveraux QL, Takahashi R, Salvesen Gs, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 1997;16:6914–6925. 89. Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.
J Cell Biol 1997;138:1379–1394. 119. Rudel T, Bokoch GM. Membrane and morphological changes in apoptotic cells regulated by caspasemediated activation of PAK2. Science 1997;276:1571–1574. 120. Martin SJ, O’Brien GA, Nishioka WK, et al. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J Biol Chem 1995;270:6425–6428. 121. Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A, Olson MF. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol 2001;3:339–345.
A unified model for apical caspase activation. Mol Cell 2003; 11:529–541. 60. Donepudi M, Sweeney AM, Briand C, Grutter MG. Insights into the regulatory mechanism for caspase8 activation. Mol Cell 2003;11:543–549. 61. Juo P, Kuo CJ, Yuan J, Blenis J. Essential requirement for caspase-8/FLICE in the initiation of the Fasinduced apoptotic cascade. Curr Biol 1998;8:1001–1008. 62. Yeh WC, Pompa JL, McCurrach ME, et al. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.