Download Current Opinion in Neurology June 2010 by Peter Goadsby, Wendy Ziai, Renaud Du Pasquier PDF

By Peter Goadsby, Wendy Ziai, Renaud Du Pasquier

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Thus, on the basis of these data, it seems that SLE rather than rituximab may be a trigger of PML [78]. Of note, no case of PML has been reported so far in MS patients treated with rituximab [74]. Nevertheless, these reassuring data are mitigated by the findings of Goldberg et al. [79], who followed 338 adult lymphoma patients with autologous peripheral blood stem cell transplantation. Two hundred and seventysix of them received a conditioning regimen consisting of carmustine, etoposide, cytarabine and cyclophosphamide and had no infectious complications, whereas among the 62 patients who received the same conditioning regimen and rituximab, two patients developed PML, another had a cytomegalovirus (CMV) pneumonitis and a fourth one a CMV retinitis [79].

4 Koralnik IJ. Progressive multifocal leukoencephalopathy revisited: has the disease outgrown its name? Ann Neurol 2006; 60:162–173. 5 Ammassari A, Cingolani A, Pezzotti P, et al. AIDS-related focal brain lesions in the era of highly active antiretroviral therapy. Neurology 2000; 55:1194– 1200. 6 Gheuens S, Pierone G, Peeters P, Koralnik IJ. Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry 2010; 81:247–254. 7 Egli A, Infanti L, Dumoulin A, et al.

Leukodystrophies and other genetic metabolic leukoencephalopathies in children and adults. Brain Dev 2009; 32:82–89. Comprehensive overview on recently known leukodystrophies. 7  8 Ko¨hler W. Diagnostic algorithm for the differentiation of leukodystrophies in early MS. J Neurol 2008; 255 (Suppl 6):123–126. 9 Schiffmann R, van der Knaap MS. Invited article: an MRI-based approach to  the diagnosis of white matter disorders. Neurology 2009; 72:750–759. Long-lasting clinical experiences and results from pattern recognition analysis in an extensively large number of known and unknown leukodystrophies in children and adults are condensed in a MRI-based algorithm of great value for treating clinicians.

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