Download Clin-alert 2001 : a quick reference to adverse clinical by Joyce Generali PDF
By Joyce Generali
Provides a compilation of abstracts from the former year's Clin-Alert e-newsletter, which collects, summarizes and studies newly released information about major adversarial drug results and drug interactions. The abstracts are prepared alphabetically inside of every one drug category. assurance extends to replacement drugs and natural remedies. Sep.
summary: provides a compilation of abstracts from the former year's Clin-Alert e-newsletter, which collects, summarizes and reviews newly released information about major opposed drug results and drug interactions. The abstracts are prepared alphabetically inside every one drug type. assurance extends to replacement medicinal drugs and natural cures. Sep
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Extra resources for Clin-alert 2001 : a quick reference to adverse clinical events
025 in approximately 66% of the samples, results did not differ from baseline. In contrast, crystalluria, which was absent at baseline measurement, occurred in l1% at week two, in 28% by week four, and in 25% till the end of the study. Intermittent crystalluria occurred in most patients (31) but almost one third (18) never developed crystalluria during therapy. Crystalluria was more frequently associated with high urine pH but data. The authors qoncluded that most patients are not adequately hydrated during indinavir therapy, increasing the risk of crystal formation.
Arrhythmias resolved and the QTc intervals normalized within three days and three weeks, respectively after fluconazole was stopped. All other medications remained the same. The authors concluded that elevated fluconazole levels were responsible for QT prolongation and Torsades de pointes in this patient. They noted that intraperitoneal administration of fluconazole may increase systemic absorption and result in increased serum concentrations. Wassmann S et a1 (Univ Cologne, 50924 Cologne, Germany) Long QT syndrome and torsades de pointes in a patient receiving fluconazole.
Ca) Prospective study of urinalysis abnormalities in HIV positive individuals treated with indinavir. Am J Kidney Diseases 36(3):507-515 (Sep) 2000 INDINAVIR AND ST. JOHN'S WORT Interaction: Decreased lndinavir Concentrations, FDA Advisory On February loth, 2000 the FDA published a public health advisory regarding a recent NIH study which demonstrated a significant drug interaction between St. John's wort (hypericum perforatum) and indinavir. Concurrent administration resulted in decreased indinavir concentrations possibly related to cytochrome P450 isoenzyme induction.