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By T.E. Lane (Editor)
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Extra info for Chemokines and Viral Infection (Current Topics in Microbiology and Immunology)
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31 NK Cell Responses in MCMV Infection . . . . . . . . . . . . . 32 NK Cell Inﬂammatory Responses in Liver During MCMV Infection . . . 3 CCL3/MIP-1α: Primary Mediator of NK Cell Inﬂammation . . . . . MIP-1α and Antiviral Defenses: The Cytokine and Chemokine Networks . The Type 1 Interferons (IFN-α/β) Association . . . . . . . . . . The CXCL9/Mig Association . . . . . . . . . . . . . . . . 1 CCL2/MCP-1: The First Link . .
In vitro stimulation of naïve liver leukocytes obtained from immunocompetent mice with rIFN-α was shown to generate a dosedependent induction of MCP-1. Together, these studies clearly establish that the induction of MCP-1 protein in liver is dependent on IFN-α/β-mediated functions. Cytokine and Chemokine Networks: Pathways to Antiviral Defense 37 Fig. 2a, b Kinetics of MCP-1 and MIP-1α during MCMV infection in liver. Infected intraperitoneally with 5×104 plaque-forming units (pfu) MCMV were 129 mice.