Download Fluorine in Medicinal Chemistry and Chemical Biology by Iwao Ojima PDF

By Iwao Ojima

The extreme strength of fluorine-containing molecules in medicinal chemistry and chemical biology has been famous through researchers open air of the normal fluorine chemistry box, and therefore a brand new wave of fluorine chemistry is quickly increasing its biomedical frontiers. With a number of of the easiest promoting medicines on this planet crucially containing fluorine atoms, the incorporation of fluorine to drug leads has turn into an important perform in biomedical learn, specifically for drug layout and discovery in addition to development.Focusing at the exact and demanding roles that fluorine performs in medicinal chemistry and chemical biology, this publication studies fresh advances and destiny customers during this quickly constructing box. subject matters lined include:Discovery and improvement of fluorine containing medications and drug candidates.New and effective artificial tools for medicinal chemistry and the optimisation of fluorine-containing drug candidates.Structural and chemical biology of fluorinated amino acids and peptides.Fluorine labels as probes in metabolic research, protein engineering and scientific diagnosis.Applications of 19F NMR spectroscopy in biomedical research.An appendix provides a useful index of all fluorine-containing medications which were licensed by way of the U.S. meals and Drug management, together with info on constitution and pharmaceutical action.Fluorine in Medicinal Chemistry and Chemical Biology will function a superb reference resource for graduate scholars in addition to educational and business researchers who are looking to benefit from fluorine in biomedical learn.

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Download Amorphous Solid Dispersions: Theory and Practice by Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, PDF

By Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A. Waseem Malick

This quantity bargains a accomplished consultant at the idea and perform of amorphous stable dispersions (ASD) for dealing with demanding situations linked to poorly soluble medications. In twenty-three inclusive chapters, the e-book examines thermodynamics and kinetics of the amorphous country and amorphous reliable dispersions, ASD applied sciences, excipients for stabilizing amorphous good dispersions resembling polymers, and ASD production applied sciences, together with spray drying, scorching soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation expertise (MBP). every one expertise is illustrated via particular case experiences. moreover, committed sections conceal analytical instruments and applied sciences for characterization of amorphous reliable dispersions, the prediction of long term balance, and the improvement of appropriate dissolution equipment and regulatory facets. The e-book additionally highlights destiny applied sciences at the horizon, reminiscent of supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.

Amorphous sturdy Dispersions: concept and perform is a helpful connection with pharmaceutical scientists attracted to constructing bioavailable and therapeutically powerful formulations of poorly soluble molecules on the way to increase those applied sciences and strengthen larger medicinal drugs for the future.

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Download Pharmacology: An Introduction by Henry Hitner, Barbara Nagle PDF

By Henry Hitner, Barbara Nagle

Pharmacology, 6e by means of Hitner/Nagle is quite readable, with brief chapters that hyperlink conception to perform; content material that's serious about the need-to-know info not to overload the reader; very good tables and contours reminiscent of sufferer management and tracking packing containers. This re-creation now has a 4-color layout with all new pictures and illustrations. bankruptcy stories were revisited so as to add extra challenge varieties and an workout development from easy to complicated. the entire suite of teacher fabrics is on the market. Hitner 6e has attach Plus, together with LearnSmart: Pharmacology, physique procedure and pharmacology animations, best 250 prescription drugs, Dosage Calculations routines, and extra.

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Download Thermodynamics of Pharmaceutical Systems : An Introduction by Kenneth A. Connors PDF

By Kenneth A. Connors

Reports of thermodynamics usually fail to illustrate how the mathematical intricacies of the topic relate to useful laboratory purposes. Thermodynamics of Pharmaceutical platforms makes those connections transparent, emphasizing particular functions to pharmaceutical platforms in a examine created particularly for modern curriculums at schools of pharmacy. scholars investigating drug discovery, drug supply, and drug motion will reap the benefits of Kenneth Connors’s authoritative therapy of the basics of thermodynamics in addition to his cognizance to drug molecules and experimental issues. an in depth appendix that stories the maths had to grasp the drugstore curriculum proves a useful reference. Connors divides his different textual content into 3 sections: easy Thermodynamics, Thermodynamics of actual techniques, and Thermodynamics of Chemical strategies; chapters contain: strength and the 1st legislation of Thermodynamics The Entropy idea part adjustments Solubility Acid-Base Equilibria Noncovalent Binding Equilibria Thermodynamics needn't be a secret nor be restrained to the world of mathematical concept. Thermodynamics of Pharmaceutical structures introduces scholars of pharmacy to the profound thermodynamic functions within the laboratory whereas additionally serving as a convenient source for training researchers.

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Download Physik für Biologen und Mediziner by Dr. Olaf Fritsche (auth.) PDF

By Dr. Olaf Fritsche (auth.)

Ein Physikbuch für Studierende der Lebenswissenschaften, in dem das Leben im Vordergrund steht: Zusammenhänge verstehen statt reine Fakten pauken

Wer wissen will, wie das Leben vom Biomolekül über die Zelle bis zum Menschen funktioniert, muss daher die Grundzüge der physikalischen Gesetze, nach denen es arbeitet, verstehen. Physik für Biologen und Mediziner erreicht dieses Ziel auf völlig neue Weise. Ausgehend von biologisch-medizinischen Strukturen und Vorgängen erklärt es schrittweise die dahinterstehenden physikalischen Konzepte. Das Lehrbuch bietet damit einen einzigartigen interdisziplinären Blick auf das Leben für angehende Wissenschaftler und Ärzte.

Physik für Biologen und Mediziner: führt Studierende anhand echter biologischer und medizinischer Phänomene in die Physik des Lebens ein; bietet Dozenten zahlreiche biologisch und medizinisch relevante Beispiele für die praxisnahe Gestaltung der eigenen Vorlesung; verbindet Biologie, Medizin und Physik zu einer umfassenden Sicht auf das Leben; zeigt auf, wo physikalische Verfahren in Forschung und Klinik eingesetzt werden; erklärt schwierige Zusammenhänge mit anschaulichen Grafiken und Fotos; nutzt didaktische Elemente wie vertiefende Boxen, Fragen und Übersichten; lässt Wissenschaftler über ihre Forschung zu den physikalischen Geheimnissen des Lebens berichten

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Download Freeze-Drying/Lyophilization Of Pharmaceutical & Biological by Louis Rey, Joan C. May PDF

By Louis Rey, Joan C. May

Thoroughly acquainting the reader with freeze-drying fundamentals-including water houses severe to the method and mechanisms and technique of protein stabilization-Freeze-Drying/Lyophilization of Pharmaceutical and organic items, moment version carves useful guidance from the very most modern theoretical study, applied sciences, and commercial procedures-ensuring the easiest execution of steps from closure guidance and regulatory keep watch over of goods to apparatus sterilization and approach validation.

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Download Drug Delivery: Fundamentals and Applications by Anya M Hillery, Kinam Park PDF

By Anya M Hillery, Kinam Park

This ebook presents a finished creation to complicated drug supply and concentrating on, protecting their rules, present purposes, and capability destiny advancements. This version has been up-to-date to mirror major traits and state of the art advances that experience happened because the first variation was once released. all of the unique chapters were retained, however the fabric therein has been up to date. 8 new chapters were additional that care for solely new applied sciences and approaches.

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