Download Carbohydrate Drug Design by Anatole A. Klyosov, Zbigniew J. Witczak, and David Platt PDF

By Anatole A. Klyosov, Zbigniew J. Witczak, and David Platt (Eds.)

content material: assessment. Carbohydrates and drug layout: what's new during this booklet / Anatole A. Klyosov --
Carbohydrate therapeutics: new advancements and techniques / Zbigniew J. Witczak --
melanoma. improvement of a polysaccharide as a automobile to enhance the efficacy of chemotherapeutics / David Platt, Anatole A. Klyosov, and Eliezer Zomer --
DAVANAT and colon melanoma: preclinical and scientific (phase I) stories / Anatole A. Klyosov, Eliezer Zomer, and David Platt --
Synthesis and organic task of doxo-galactose and doxo-galactomannan, new conjugates of doxorubicin with D-galactose and 1,4, [beta]-D-galactomannan / Anatole A. Klyosov ... [et al.] --
Human immunodeficiency virus. Carbohydrate-based vaccines opposed to HIV/Aids / Lai-Xi Wang --
towards a carbohydrate-based HIV-1 vaccine / Daniel Calarese ... [et al.] --
Pathogen administration. Cationic polysaccharides within the remedy of pathogenic Candida infections / Avital Mazar Ben-Josef, David Platt, and Eliezer Zomer --
New ways in synthesis and computational reports. artificial how to comprise [alpha]-linked 2-amino-2-deoxy-D-glucopyranoside and 2-amino-2-deoxy-D-galactopyranoside residues into glycoconjugate constructions / Robert J. Kerns and Peng Wei --
Systematic synthesis of aminosugars and their stereoselective glycosylation / Jinhua Wang and Cheng-Wei Tom Chang --
useful purposes of computational experiences of the glycosylation response / Dennis M. Whitfield and Tomoo Nukada.

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Extra resources for Carbohydrate Drug Design

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The authors describe their development o f a new algebra - to quantitatively describe the conformations o f six-membered rings that dominate the chemistry o f carbohydrates - and its use in calculations aimed at understanding the mechanism o f glycosylation reactions, both enzymatic and "common chemical", and at optimizing it. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. 24 the acceptor alcohol with neighboring group participation v i a a proposed transition state. The chapter improves our current understanding o f the conformations o f pyranose sugars with protecting groups, and it is expected to give organic chemists a better tool for designing stereoselective glycosylation reactions.

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