Download Calcium : A Matter of Life or Death, Volume 41 by Joachim Krebs, Marek Michalak PDF

By Joachim Krebs, Marek Michalak

Calcium is a flexible provider of signs regulating many points of mobile job comparable to fertilization to create a brand new lifestyles and programmed cellphone dying to finish it. Calcium homeostasis is precisely managed by way of channels, pumps and exchangers functioning as gates for calcium access and unencumber. on condition that calcium is this type of flexible messenger the sector of calcium signaling is always and speedily increasing. This publication stories the newest advancements in calcium signaling via major specialists within the box. it's a state of the art precis of our current wisdom during this speedy becoming box and gives perception into the awesome development made in lots of parts of calcium signaling, whereas reminding us of ways a lot continues to be realized.

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Extra resources for Calcium : A Matter of Life or Death, Volume 41

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Genet. 9, 1131–1140. T. L. (2004) J. Assoc. Res. Otolaryngol. 5, 99–110. , Di Leva, F. and Carafoli, E. (2006) manuscript in preparation. J. Krebs and M. V. All rights reserved. 1016/S0167-7306(06)41002-4 CHAPTER 2 The evolution of the biochemistry of calcium Robert J. P. uk Abstract The chemistry of the calcium (Ca) ion does not appear of great interest, but it has been an essential element in biological evolution. Initially, procaryotic cells treated it as an intracel­ lular poison rejecting it together with sodium and chloride ions.

Initially, procaryotic cells treated it as an intracel­ lular poison rejecting it together with sodium and chloride ions. The resulting functions of Ca apart from being pumped out of cells were on the cell exterior, assisting such activities as wall stability and extra-cytoplasmic digestion. These functions have continued in a modified form to this day. The great significance of Ca arose with the very beginnings of eucaryote multicompartment cells. Here communication between compartments is essential, and addition­ ally a great advantage to cell survival, now of longer life, arose from knowledge of the extracellular environment.

The protease calpain is one striking example: it contains a calmodulin like Ca2+-binding domain covalently 8 E. Carafoli bound within the catalytic subunit. Then, a separate EF-hand subunit also interacts with the catalytic subunit. Finally, numerous proteins, enzymes or otherwise, contain specific binding sites for Ca2+, which thus regulates their activity directly, without the intermediation of proteins like calmodulin. These proteins, of which one important example is protein kinase C, can thus also be considered as bona fide Ca2+ sensors.

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