Download Calcium: A Matter of Life or Death by Joachim Krebs, Marek Michalak PDF

By Joachim Krebs, Marek Michalak

Calcium is a flexible service of indications regulating many facets of mobile task corresponding to fertilization to create a brand new lifestyles and programmed cellphone demise to finish it. Calcium homeostasis is precisely managed by way of channels, pumps and exchangers functioning as gates for calcium access and free up. provided that calcium is this sort of flexible messenger the sphere of calcium signaling is regularly and quickly increasing. This booklet experiences the newest advancements in calcium signaling via best specialists within the box. it's a state of the art precis of our current wisdom during this fast turning out to be box and offers perception into the amazing growth made in lots of parts of calcium signaling, whereas reminding us of ways a lot continues to be realized.

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Additional info for Calcium: A Matter of Life or Death

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Whereas not all described cases of m or m calpain involvement in pathology have been convincingly shown to have in vivo significance, this is instead clearly the case for two tissue-specific atypical calpains, calpain III (p94) and calpain X. Calpain II is monomeric and muscle-specific: inactivating mutations of its gene are responsible for a mild form of limb girdle muscular dystrophy (type 2A) [40]. The problem with calpain III is that only one plausible substrate in vivo has so far been described: IkB, the inhibitor of the NF-kB, which is the inhibitor of the Rel transcription factor family [41].

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