Download Advances in Spinal Stabilization by L. Dade Lunsford, Brian R. Subach, Gerald E. Rodts PDF

By L. Dade Lunsford, Brian R. Subach, Gerald E. Rodts

Dramatic adjustments in spinal stabilization have taken position within the final years and the velocity of switch maintains to speed up. This quantity is a superb reflect of the evolution of spinal stabilization. It brings jointly the most recent and so much finished studies in minimally-invasive and novel surgical methods and spinal stabilization suggestions. Highlights in new biomaterials together with radiolucent, bioresorbable, and traditional titanium are mentioned via specialists. organic advances together with using bone morphogenetic protein in anterior lumbar interbody fusion in addition to computer-assisted image-guided surgical strategies are established. The part on instrumentation and strategy represents the main updated advances in surgical procedure and administration of spinal issues. Illustrations incorporated in every one bankruptcy rfile those very good papers. since it is a needs to for all surgeons acting spinal surgical procedure to maintain up to date during this fast-paced box this e-book is quintessential.

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Cellular and Genetic Approaches 25 dramroo 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 Reddi AH: Extracellular bone matrix dependent local induction of cartilage and bone. J Rheumatol Suppl 1983;11:67–69. Sampath TK, Reddi AH: Distribution of bone inductive proteins in mineralized and demineralized extracellular matrix. Biochem Biophys Res Commun 1984;119:949–954. Reddi AH: Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens.

Patients requiring neural decompression could be taken to surgery following successful bony fusion, where extensive laminectomies, facetectomies, and foraminotomies could be performed without leading to spinal instability. Figure 2 demonstrates a posterolateral spinal fusion in the lumbar region of a rabbit using percutaneous, direct gene therapy of a BMP-6 adenoviral vector, demonstrating significant bone formation with excellent union with the host transverse processes. Ex vivo BMP Gene Therapy Another approach that is currently being investigated by several research groups is ex vivo gene therapy, a technique in which osteogenic genes are inserted into cells in tissue culture, and the genetically altered cells are subsequently implanted into regions requiring bone formation in experimental animals [73].

J Cell Biochem 2002;84:509–519. Urist MR: Bone: Formation by autoinduction. Science 1965;150:893–899. Wang EA, Rosen V, Cordes P, Hewick RM, Kriz MF, Luxenberg DP, Sibley BS, Wozney JM: Purification and characterization of other distinct bone-inducing factors. Proc Natl Acad Sci USA 1988;85:9484–9488. Boden SD, Zdeblick TA, Sandhu HS, Heim SE: The use of rhBMP-2 in interbody fusion cages: Definitive evidence of osteoinduction in humans: A preliminary report. Spine 2000;25: 376–381. Bone Substitutes 37 dramroo 21 22 23 24 25 26 27 28 29 30 Subach BR, Haid RW, Rodts GE, Kaiser MG: Bone morphogenetic protein in spinal fusion: Overview and clinical update.

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