Download Advanced Pharmaceutics by Cherng-ju Kim PDF
By Cherng-ju Kim
Discussing finished variety of themes, complicated Pharmaceutics: Physicochemical rules reports all facets of actual pharmacy. The booklet explains the fundamental, mechanistic, and quantitative interpretation talents had to remedy actual pharmacy similar difficulties. the writer offers a powerful primary historical past and commonly covers thermodynamics, ionic equilibria, recommendations and distribution, floor chemistry and colloids, kinetics, diffusion, and polymer technological know-how. He outlines the newest study on diffusion via a membrane and using polymers in dosage forms.Packed with formulae and versions, the e-book demonstrates the advance of every after which describes using these types for a number of formula occasions. The author's precise clarification of the evolution of the formulae offers a transparent realizing of while and the way they're used. This bottom-up strategy delineates the evolution of the formulae and offers a transparent figuring out of while and the way they need to be used. The e-book offers an in-depth evaluate and research of dosage shape layout standards that you should speedily enforce on your daily paintings.
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Extra resources for Advanced Pharmaceutics
7. Calculate the entropy change when hot water (80°C) comes in contact with cold water (5°C). The heat capacity of water at constant pressure is 75 J/K/mol. Heat is not lost to the surroundings during this operation. 8. Calculate the free energy change of hydrolysis of glycylglycine at 25°C and 1 atm in a dilute aqueous solution at 37°C and 1 atm: H 3 N + CH 2 CONHCH 2 COO − (aq) + H 2 O(l) → 2H 3 N + CH 2 COO − (aq) 9. Derive the equation ∂S ∂V = − ∂P T ∂T P 10. Calculate the equilibrium constant for the following reaction at 25°C: CH 3COCOOH(l) → CH 3COH(g) + CO 2 (g) 11.
Van Holde, Biochemistry, Benjamin/Cummings, Redwood City, CA, 1990, Chapter 3. 9. O. , Ionic Reactions and Equilibria, MacMillan, New York, 1967, Chapters 5 and 6. 10. J. M. Smith and H. C. , McGraw-Hill, New York, 1975, Chapters 2–5. 11. I. , K. Sauer, and J. C. , Prentice Hall, NJ, 1995, Chapters 1–5. 12. V. R. Williams, W. L. Mattrice, and H. B. , W. H. , San Francisco, 1978, Chapters 1–3. PROBLEMS 1. Calculate the work done when a drop of ice (1 µm) evaporates to water at 0°C and 1 atm. 915 g/cm3, respectively.
Fm Page 45 Friday, January 30, 2004 6:12 PM 2 Ionic Equilibrium Many commercially available and investigational drugs are anionic or cationic salt forms of weak acids or weak bases (undissociated). ) are strongly dependent upon the degree of ionization, the pH of the solution, and other constituents in the solutions of the drugs. In this chapter, ionic equilibrium calculations will be demonstrated in order to facilitate study of their properties. 1) Three species are present in the aqueous solution of the strong acid: H+, OH−, and Cl−.