Download Acute Promyelocytic Leukemia: Molecular Genetics, Mouse by Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor) PDF

By Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)

Over the last 10 years, paintings on acute promyelocytic leukemia (APL) has develop into the paradigm of translational study that started with the invention of a recurrent chromosomal translocation, through the id of the genes and proteins concerned, discovering their molecular features in transcriptional regulate, setting up mouse versions and culminating within the improvement  of precise treatment.

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Additional info for Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313)

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Additionally, PLZF interacts with Bmi-1, a member of the Polycomb protein family implicated in chromatin remodeling [4]. Work is ongoing in our laboratory and others to define a precise role for PLZF in repression-associated changes in chromatin structure. Interestingly, there is a stretch of acidic residues C-terminal to the BTB domain of PLZF that, when tethered to GAL4, acts as a transcriptional activator [44]. Activation is not observed with full-length PLZF protein in the majority of biological systems.

5. Extending differentiation therapy to other leukemias. Acknowledgements Thanks to Dr. Galit Rosen for Fig. 1 as well as Drs. Michael Bishop, Hugues de Thé, Jeffrey Lawrence, Frank McCormick, and Kevin Shannon for their continuing interest and support. Scott Kogan is a Scholar of the Leukemia and Lymphoma Society. References Bensi L, Longo R, Vecchi A, Messora C, Garagnani L, Bernardi S, Tamassia MG, Sacchi S (1995) Bcl-2 oncoprotein expression in acute myeloid leukemia. Haematologica 80:98–102 Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, Atwater S, Bishop JM (1997) a PMLRAR alpha transgene initiates murine acute promyelocytic leukemia.

Grimwade D, Gorman P, Duprez E, Howe K, Langabeer S, Oliver F, Walker H, Culligan D, Waters J, Pomfret M, Goldstone A, Burnett A, Freemont P, Sheer D, Solomon E (1997) Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia. Blood 90:4876–4885 23. Guidez F, Howell L, Isalan M, Cebrat M, Alani RM, Ivins S, Hormaeche I, McConnell MJ, Pierce S, Cole PA, Licht J, Zelent A (2005) Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.

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