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16] Saglani K, Malmstrom AS, Pelkonen LP, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005;171:722–7. [17] Krawiec ME, Westcott JY, Chu HW, et al. Persistent wheezing in very young children is associated with lower respiratory inflammation. Am J Respir Crit Care Med 2001;163:1338–43. [18] Le Bourgeois M, Goncalves M, Le Clainche L, et al. 3 years old with severe recurrent wheezing. Chest 2002;122:761–3. [19] Covar RA, Spahn JD, Murphy JR, et al.

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Progression of asthma measured by lung function in the childhood asthma management program. Am J Respir Crit Care Med 2004;170:234–41. [20] Crapo RO, Casaburi R, Coates AL, et al. Guidelines for methacholine and exercise challenge testing 1999. Am J Respir Crit Care Med 2000;161:309–29. [21] Castro-Rodriguez JA, Holberg CJ, Wright AL, et al. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000;162:1403–6. [22] Guilbert TW, Morgan WJ, Zeiger RS, et al.

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